Published Scientific Papers

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Peer Reviewed Articles

  1. Firsova, D., Calabro, K., Lasserre, P., Reyes, F., & Thomas, O. P. (2017). Isoguanosine derivatives from the Northeastern Atlantic sponge Clathria (Microciona) strepsitoxa. Tetrahedron Letters, 58(49), 4652-4654.
  2. Fraga, M., Vilariño, N., Louzao, M. C., Molina, L., López, Y., Poli, M., & Botana, L. M. (2017). First identification of palytoxin-like molecules in the atlantic coral species palythoa canariensis. Analytical chemistry, 89(14), 7438-7446.
  3. Rodriguez, I., Vieytes, M. R., & Alfonso, A. (2017). Analytical challenges for regulated marine toxins. Detection methods. Current Opinion in Food Science, 18, 29-36.
  4. Louzao, M. C., Abal, P., & Vilarino, N. (2017). Toxicity equivalence factors for regulated and non-regulated marine toxins. Current Opinion in Food Science, 18, 64-70.
  5. Amar, M., Aráoz, R., Iorga, B. I., Yasumoto, T., Servent, D., & Molgó, J. (2018). Prorocentrolide-A from cultured Prorocentrum lima dinoflagellates collected in Japan blocks sub-types of nicotinic acetylcholine receptors. Toxins, 10(3), 97.
  6. Turner, A. D., Fenwick, D., Powell, A., Dhanji-Rapkova, M., Ford, C., Hatfield, R. G., … & Stebbing, P. (2018). New invasive nemertean species (Cephalothrix simula) in England with high levels of tetrodotoxin and a microbiome linked to toxin metabolism. Marine drugs, 16(11), 452.
  7. Cunha, I., Biltes, R., Sales, M. G. F., & Vasconcelos, V. (2018). Aptamer-based biosensors to detect aquatic phycotoxins and cyanotoxins. Sensors, 18(7), 2367.
  8. Guillen, P. O., Gegunde, S., Jaramillo, K. B., Alfonso, A., Calabro, K., Alonso, E., … & Thomas, O. P. (2018). Zoanthamine alkaloids from the zoantharian Zoanthus cf. pulchellus and their effects in neuroinflammation. Marine drugs, 16(7), 242.
  9. Afoullouss, S., Calabro, K., Genta-Jouve, G., Gegunde, S., Alfonso, A., Nesbitt, R., … & Thomas, O. P. (2018). Treasures from the deep: Characellides as anti-inflammatory lipoglycotripeptides from the sponge Characella pachastrelloides. Organic letters, 21(1), 246-251.
  10. Rodríguez, I., Alfonso, A., González-Jartín, J. M., Vieytes, M. R., & Botana, L. M. (2018). A single run UPLC-MS/MS method for detection of all EU-regulated marine toxins. Talanta, 189, 622-628.
  11. Rey, V., Botana, A. M., Antelo, A., Alvarez, M., & Botana, L. M. (2018). Rapid analysis of paralytic shellfish toxins and tetrodotoxins by liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column. Food chemistry, 269, 166-172.
  12. Boente-Juncal, A., Méndez, A. G., Vale, C., Vieytes, M. R., & Botana, L. M. (2018). In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development. ACS chemical neuroscience, 9(6), 1441-1452.
  13. Boente-Juncal, A., Vale, C., Alfonso, A., & Botana, L. M. (2018). Synergistic effect of transient receptor potential antagonist and amiloride against maitotoxin induced calcium increase and cytotoxicity in human neuronal stem cells. ACS chemical neuroscience, 9(11), 2667-2678.
  14. Rubiolo, J. A., Vale, C., Boente-Juncal, A., Hirama, M., Yamashita, S., Camiña, M., … & Botana, L. M. (2018). Transcriptomic analysis of ciguatoxin-induced changes in gene expression in primary cultures of mice cortical neurons. Toxins, 10(5), 192.
  15. Abal, P., Louzao, M. C., Suzuki, T., Watanabe, R., Vilariño, N., Carrera, C., … & Botana, L. M. (2018). Toxic action reevaluation of okadaic acid, dinophysistoxin-1 and dinophysistoxin-2: toxicity equivalency factors based on the oral toxicity study. Cellular Physiology and Biochemistry, 49(2), 743-757.
  16. Vilariño, N., Louzao, M. C., Abal, P., Cagide, E., Carrera, C., Vieytes, M. R., & Botana, L. M. (2018). Human poisoning from marine toxins: Unknowns for optimal consumer protection. Toxins, 10(8), 324.
  17. Benoit, E., Couesnon, A., Lindovsky, J., Iorga, B. I., Aráoz, R., Servent, D., … & Molgó, J. (2019). Synthetic pinnatoxins A and G reversibly block mouse skeletal neuromuscular transmission in vivo and in vitro. Marine drugs, 17(5), 306.
  18. Hatfield, R. G., Bean, T., Turner, A. D., Lees, D. N., Lowther, J., Lewis, A., & Baker-Austin, C. (2019). Development of a TaqMan qPCR assay for detection of Alexandrium spp and application to harmful algal bloom monitoring. Toxicon: X, 2, 100011.
  19. Silva, M., Rodríguez, I., Barreiro, A., Kaufmann, M., Neto, A. I., Hassouani, M., … & Vasconcelos, V. (2019). Tetrodotoxins occurrence in non-traditional vectors of the north atlantic waters (Portuguese maritime territory, and morocco coast). Toxins, 11(6), 306.
  20. Lamas, J. P., Arévalo, F., Moroño, Á., Correa, J., Muñíz, S., & Blanco, J. (2019). Detection and spatio-temporal distribution of pinnatoxins in shellfish from the Atlantic and Cantabrian coasts of Spain. Toxins, 11(6), 340.
  21. Anderson, C. R., Berdalet, E., Kudela, R. M., Cusack, C. K., Silke, J., O’Rourke, E., … & Morell, J. (2019). Scaling up from regional case studies to a global harmful algal bloom observing system. Frontiers in Marine Science, 6, 250.
  22. Boente-Juncal, A., Álvarez, M., Antelo, Á., Rodríguez, I., Calabro, K., Vale, C., … & Botana, L. M. (2019). Structure elucidation and biological evaluation of maitotoxin-3, a homologue of gambierone, from Gambierdiscus belizeanus. Toxins, 11(2), 79.
  23. Otero, P., Miguéns, N., Rodríguez, I., & Botana, L. M. (2019). LC–MS/MS analysis of the emerging toxin pinnatoxin-G and high levels of esterified OA group toxins in Galician commercial mussels. Toxins, 11(7), 394.
  24. Abal, P., Louzao, M. C., Vilariño, N., Vieytes, M. R., & Botana, L. M. (2019). Acute toxicity assessment: Macroscopic and ultrastructural effects in mice treated with oral tetrodotoxin. Toxins, 11(6), 305.
  25. Boente-Juncal, A., Vale, C., Cifuentes, M., Otero, P., Camiña, M., Rodriguez-Vieytes, M., & Botana, L. M. (2019). Chronic in vivo effects of repeated exposure to low oral doses of tetrodotoxin: Preliminary evidence of nephrotoxicity and cardiotoxicity. Toxins, 11(2), 96.
  26. Aráoz, R., Barnes, P., Séchet, V., Delepierre, M., Zinn-Justin, S., Molgó, J., … & Servent, D. (2020). Cyclic imine toxins survey in coastal European shellfish samples: Bioaccumulation and mode of action of 28-O-palmitoyl ester of pinnatoxin-G. First report of portimine-A bioaccumulation. Harmful Algae, 98, 101887.
  27. Molgó, J., Schlumberger, S., Sasaki, M., Fuwa, H., Louzao, C. M., Botana, L. M., … & Benoit, E. (2020). Gambierol enhances evoked quantal transmitter release and blocks a potassium current in motor nerve terminals of the mouse neuromuscular junction.
  28. Molgó, J., Schlumberger, S., Sasaki, M., Fuwa, H., Louzao, M. C., Botana, L. M., … & Benoit, E. (2020). Gambierol Potently Increases Evoked Quantal Transmitter Release and Reverses Pre-and Post-Synaptic Blockade at Vertebrate Neuromuscular Junctions. Neuroscience, 439, 106-116.
  29. Turner, A. D., Dhanji-Rapkova, M., Fong, S. Y., Hungerford, J., McNabb, P. S., Boundy, M. J., & Harwood, D. T. (2020). Ultrahigh-performance hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of paralytic shellfish toxins and tetrodotoxin in mussels, oysters, clams, cockles, and scallops: Collaborative study. Journal of AOAC International, 103(2), 533-562.
  30. Hatfield, R. G., Batista, F. M., Bean, T. P., Fonseca, V. G., Santos, A., Turner, A. D., … & Martinez-Urtaza, J. (2020). The application of nanopore sequencing technology to the study of dinoflagellates: a proof of concept study for rapid sequence-based discrimination of potentially harmful algae. Frontiers in microbiology, 11, 844.
  31. Dean, K. J., Hatfield, R. G., Lee, V., Alexander, R. P., Lewis, A. M., Maskrey, B. H., … & Turner, A. D. (2020). Multiple new paralytic shellfish toxin vectors in offshore North Sea benthos, a deep secret exposed. Marine Drugs, 18(8), 400.
  32. Tamele, I. J., Silva, M., & Vasconcelos, V. (2019). The incidence of marine toxins and the associated seafood poisoning episodes in the African countries of the Indian Ocean and the Red Sea. Toxins, 11(1), 58.
  33. Pisapia, F., Sibat, M., Watanabe, R., Roullier, C., Suzuki, T., Hess, P., & Herrenknecht, C. (2020). Characterization of maitotoxin‐4 (MTX4) using electrospray positive mode ionization high‐resolution mass spectrometry and UV spectroscopy. Rapid Communications in Mass Spectrometry, 34(19), e8859.
  34. Shin, H. H., Li, Z., Réveillon, D., Rovillon, G. A., Mertens, K. N., Hess, P., … & Lim, W. A. (2020). Centrodinium punctatum (Dinophyceae) produces significant levels of saxitoxin and related analogs. Harmful Algae, 100, 101923.
  35. Nascimento, S. M., Neves, R. A., De’Carli, G. A., Borsato, G. T., Da Silva, R. A., Melo, G. A., … & Salgueiro, F. (2020). Ostreopsis cf. ovata (Dinophyceae) molecular phylogeny, morphology, and detection of ovatoxins in strains and field samples from Brazil. Toxins, 12(2), 70.
  36. Landrigan, P. J., Stegeman, J. J., Fleming, L. E., Allemand, D., Anderson, D. M., Backer, L. C., … & Rampal, P. (2020). Human health and ocean pollution. Annals of global health, 86(1).
  37. Otero, P., Vale, C., Boente-Juncal, A., Costas, C., Louzao, M. C., & Botana, L. M. (2020). Detection of Cyclic Imine Toxins in Dietary Supplements of Green Lipped Mussels (Perna canaliculus) and in Shellfish Mytilus chilensis. Toxins, 12(10), 613.
  38. González-Jartín, J. M., de Castro Alves, L., Alfonso, A., Piñeiro, Y., Vilar, S. Y., Rodríguez, I., … & Botana, L. M. (2020). Magnetic nanostructures for marine and freshwater toxins removal. Chemosphere, 256, 127019.
  39. Boente-Juncal, A., Raposo-García, S., Costas, C., Louzao, M. C., Vale, C., & Botana, L. M. (2020). Partial blockade of human voltage-dependent sodium channels by the marine toxins azaspiracids. Chemical research in toxicology, 33(10), 2593-2604.
  40. Boente-Juncal, A., Vale, C., Camiña, M., Cifuentes, J. M., Vieytes, M. R., & Botana, L. M. (2020). Reevaluation of the acute toxicity of palytoxin in mice: Determination of lethal dose 50 (LD50) and no-observed-adverse-effect level (NOAEL). Toxicon, 177, 16-24.
  41. Boente-Juncal, A., Raposo-García, S., Vale, C., Louzao, M. C., Otero, P., & Botana, L. M. (2020). In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin. Toxins, 12(8), 489
  42. Dhanji-Rapkova, M., Turner, A. D., Baker-Austin, C., Huggett, J. F., & Ritchie, J. M. (2021). Distribution of Tetrodotoxin in Pacific Oysters (Crassostrea gigas). Marine Drugs, 19(2), 84.
  43. O’Neill, A., Morrell, N., Turner, A. D., & Maskrey, B. H. (2021). Method performance verification for the combined detection and quantitation of the marine neurotoxins cyclic imines and brevetoxin shellfish metabolites in mussels (Mytilus edulis) and oysters (Crassostrea gigas) by UHPLC-MS/MS. Journal of Chromatography B, 1179, 122864.
  44. Camacho-Muñoz, D., Waack, J., Turner, A. D., Lewis, A. M., Lawton, L. A., & Edwards, C. (2021). Rapid uptake and slow depuration: Health risks following cyanotoxin accumulation in mussels?. Environmental Pollution, 271, 116400.
  45. Kershaw, J. L., Jensen, S. K., McConnell, B., Fraser, S., Cummings, C., Lacaze, J. P., … & Hall, A. J. (2021). Toxins from harmful algae in fish from Scottish coastal waters. Harmful Algae, 105, 102068.
  46. Yon, T., Sibat, M., Réveillon, D., Bertrand, S., Chinain, M., & Hess, P. (2021). Deeper insight into Gambierdiscus polynesiensis toxin production relies on specific optimization of high-performance liquid chromatography-high resolution mass spectrometry. Talanta, 232, 122400.
  47. Lamas, J. P., Arévalo, F., Moroño, Á., Correa, J., Rossignoli, A. E., & Blanco, J. (2021). Gymnodimine A in mollusks from the north Atlantic Coast of Spain: Prevalence, concentration, and relationship with spirolides. Environmental Pollution, 279, 116919.
  48. Otero, P., Vale, C., Boente-Juncal, A., Costas, C., Louzao, M. C., & Botana, L. M. (2021). Mussels Based Food Supplements: Evaluation of Emerging Marine Toxins is a Necessary Evil. Proceedings 2021, 65, x.
  49. Otero, P., Vale, C., Boente-Jucal, S., Costas, C., Louzao, M. C., & Botana, L. M. (2021). Contamination Status of Lipophilic Marine Toxins in Commercial Shellfish from Spain, Chile and South East Pacific.
  50. Louzao, M. C., Abal, P., Costas, C., Suzuki, T., Watanabe, R., Vilariño, N., … & Botana, L. M. (2021). DSP toxin distribution across organs in mice after acute oral administration. Marine Drugs, 19(1), 23.
  51. Louzao, M. C., Costas, C., Abal, P., Suzuki, T., Watanabe, R., Vilariño, N., … & Botana, L. M. (2021). Serotonin involvement in okadaic acid-induced diarrhoea in vivo. Archives of Toxicology, 1-17.
  52. Boente-Juncal, A., Raposo-García, S., Louzao, M. C., Vale, C., & Botana, L. M. (2021). Targeting Chloride Ion Channels: New Insights into the Mechanism of Action of the Marine Toxin Azaspiracid. Chemical Research in Toxicology, 34(3), 865-879.
  53. Réveillon, D.; Savar, V.; Schaefer, E.; Chevé, J.; Halm-Lemeille, M.-P.; Hervio-Heath, D.; Travers, M.-A.; Abadie, E.; Rolland, J.-L.; Hess, P., Tetrodotoxins in French Bivalve Mollusks—Analytical Methodology, Environmental Dynamics and Screening of Bacterial Strain Collections. Toxins 2021, 13 (11), 740.
  54. Tang, Z.; Qiu, J.; Wang, G.; Ji, Y.; Hess, P.; Li, A., Development of an efficient extraction method for harvesting gymnodimine-A from large-scale cultures of Karenia selliformis. Toxins 2021, 13 (11), 793.